In a mixing bowl, combine all the ingredients: brown sugar, paprika, coarse sea salt, black pepper, garlic powder, onion powder, cayenne pepper, ground cumin, dried thyme, and dried oregano. This blend of spices will create a balanced flavor profile that enhances the brisket.

Using a whisk, mix the ingredients thoroughly until they are well combined and no clumps remain. This ensures that each bite of brisket will have an even distribution of flavor.

Transfer the rub into an airtight container for storage. This rub can be kept in a cool, dry place for up to 6 months, allowing the flavors to meld and intensify over time.